Monomorphism of cytidine (Cyd) vs. polymorphism of 2'deoxycytidine (dCyd). Structural and functional consequences
Abstract
It has been found that 2'deoxycytidine (dCyd) crystallizes in different forms, denoted dCyd A, dCyd B and dCyd C·H 2O. In the crystal lattice of the newly discovered form dCydC·H 2O there is a crystalline water molecule present. The monohydrate of dCydC, under suitable conditions (RT, over P 2O 5, 48h), undergoes transformation into the fully dehydrated form—dCydC anhydro. The whole process of de- and re-hydratation has been observed by FTIR-PAS spectroscopy. The nature of the differences and similarities between structural and functional properties of crystalline forms of 2'dCyd and Cyd molecules has been discussed.
- Publication:
-
Journal of Molecular Structure
- Pub Date:
- December 1997
- DOI:
- 10.1016/S0022-2860(97)00244-5
- Bibcode:
- 1997JMoSt.436..627W