Crystal structure of cyclin-dependent kinase 2
Abstract
Cyclin-dependent kinase 2 (CDK2) is a member of a highly conserved family of protein klnases that regulate the eukaryotic cell cycle. The crystal structures of the human CDK2 apoenzyme and its Mg2+ATP complex have been determined to 2.4Å resolution. The structure is bi-lobate, like that of the cyclic AMP-dependent protein kinase, but contains a unique helix—loop segment that interferes with ATP and protein substrate binding and probably plays a key part in the regulation of all cyclin-dependent kinases.
- Publication:
-
Nature
- Pub Date:
- June 1993
- DOI:
- 10.1038/363595a0
- Bibcode:
- 1993Natur.363..595D