Encoding of a Homolog of the IFN-γ Receptor by Myxoma Virus
Abstract
Many poxvirus-encoded virulence factors have been identified as proteins that are secreted from infected cells. The major secreted protein (37 kilodaltons) from cells infected with myxoma virus is encoded by the M-T7 open reading frame. This protein has significant sequence similarity to the human and mouse receptors for interferon-gamma (IFN-γ). Furthermore, the myxoma M-T7 protein specifically binds rabbit IFN-γ and inhibits the biological activity of extracellular IFN-γ, one of the key regulatory cytokines in the host immune response against viral infections.
- Publication:
-
Science
- Pub Date:
- November 1992
- DOI:
- 10.1126/science.1455233
- Bibcode:
- 1992Sci...258.1369U