A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins
Abstract
Tumor necrosis factor a and B (TNF-a and TNF-B bind surface receptors on a variety of cell types to mediate a wide range of immunological responses, inflammatory reactions, and anti-tumor effects. A cDNA done encoding an integral membrane protein of 461 amino acids was isolated from a human lung fibroblast library by direct expression screening with radiolabeled TNF-a. The encoded receptor was also able to bind TNF-B. The predicted cysteine-rich extracellular domain has extensive sequence similarity with five proteins, including nerve growth factor receptor and a transcriptionally active open reading frame from Shope fibroma virus, and thus defines a family of receptors.
- Publication:
-
Science
- Pub Date:
- May 1990
- DOI:
- 10.1126/science.2160731
- Bibcode:
- 1990Sci...248.1019S