Calicheamicin γ 1{}I and DNA: Molecular Recognition Process Responsible for Site-Specificity
Abstract
Calicheamicin γ 1{}I is a recently discovered diyne-ene-containing antitumor antibiotic that cleaves DNA in a double-stranded fashion, a rarity among drugs, at specific sequences. It is proposed that the cutting specificity is due to a combination of the complementarity of the diyne-ene portion of the aglycone with DNA secondary structures and stabilization by association of the thiobenzoate-carbohydrate tail with the minor groove.
- Publication:
-
Science
- Pub Date:
- May 1989
- DOI:
- 10.1126/science.2717946
- Bibcode:
- 1989Sci...244..697Z