Current status of the Os-191 yields Ir-191m generator
Abstract
The advantages of ultrashort lived radionuclides for angiography have been well documented in recent years. Although several isotopes are potentially useful in this application (e.g., Au-195m, Ag-109m, Ir-191m), Ir-191m offers several advantages. Among these advantages are a parent isotope (Os-191) with a sufficiently long half life (15.4 d) to allow production of a generator with a reasonable shelf life, high photon yield (129 keV, 26%; 66 keV, 55%), and ease of production of the parent isotope (i.e., neutron irradiation of Os-190). Ir-191m has not, however, been widely used for radionuclide angiocardiography because of a less than optimal generator design and the assumption that the half life of Ir-191m (4.96 s) was too short to permit visualization of the left ventricle in adult patients. A generator has been developed with higher Ir-191m yield (25 to 30%/ml), lower Os-191 breakthrough ( 5 x 10 to the minus 4 power %) that is easier to assemble. In addition, the eluate of this new generator (0.001M oxalic acid/0.9% saline) does not require buffering prior to injection. It is also demonstrated that adequate studies of the left ventricle can be obtained in adults when sufficient quantities of isotope are injected.
- Publication:
-
Unknown
- Pub Date:
- 1985
- Bibcode:
- 1985csoy.book.....P
- Keywords:
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- Cardiography;
- Generators;
- Heart;
- Iridium;
- Osmium;
- Radioactive Isotopes;
- Blood Vessels;
- Calibrating;
- Clinical Medicine;
- Irradiation;
- Nuclear and High-Energy Physics