Possible role for poly(A) as an inhibitor of endonuclease activity in eukaryotic cells
Abstract
A NUMBER of laboratories have reported the isolation from eukaryotic cells of mRNAs linked covalently at their 3'-OH termini to polyadenylic add (poly(A))1-4. The chain of adenylic acid residues has been found also at the 3' termini of RNAs isolated from several well characterised viruses5-7. Although considerable evidence exists to suggest that the insertion of poly(A) on the RNA chains destined to become mRNA is a post-transcriptional event8, there is at present little understanding of the part poly(A) plays in the subsequent stages of protein synthesis.
- Publication:
-
Nature
- Pub Date:
- July 1975
- DOI:
- 10.1038/256340a0
- Bibcode:
- 1975Natur.256..340L