Kinetic Model of Conduction Changes across Excitable Membranes
Abstract
A kinetic model describing conduction changes across excitable membranes is proposed. It assumes that a population of discrete membrane sites is distributed among several distinct functional states determined by the voltage across the membrane. Interconversion of these states is postulated to occur by first-order reactions. It provides a satisfactory description of the central aspects of excitable membrane behavior, including current-time and current-voltage relationships, action potential, and effects of inhibitors.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- October 1970
- DOI:
- 10.1073/pnas.67.2.799
- Bibcode:
- 1970PNAS...67..799J