Mitotic Abnormalities in Sea Urchin Embryos Exposed to Dactinomycin
Abstract
Dactinomycin at concentrations of 10, 20, 25, and 50 μg/ml causes mitotic abnormalities in sea urchin embryos. Sister chromosome separation is impaired and anaphase bridges are frequently formed. The result is an unequal distribution of the chromosome complement to daughter cells. Possible explanations are discussed.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- November 1969
- DOI:
- 10.1073/pnas.64.3.857
- Bibcode:
- 1969PNAS...64..857K