Diaryloxazole and Diarylthiazolealkanoic Acids: Two Novel Series of Non-steroidal Anti-inflammatory Agents
Abstract
SINCE the reports of the anti-inflammatory activity of indomethacin (1-p-chlorobenzoyl-5-methoxy-2-methyl-indol-3-ylacetic acid)1 and ibufenac (p-isobutylphenylacetic acid)2, there has been much interest in the pharmacological properties of aryl and heteroarylalkanoic acids. This paper describes the anti-inflammatory activity found in two series of new alkanoic acids, namely the 2,4-di-phenylthiazol-5-ylacetic acids (I) and the β-(4,5-diphenyl-oxazol-2-yl) propionic acids (II). The thiazoles (I) were prepared by the Hantzsch method from thioamides and β-bromo-β-ketoacids, and the oxazoles (II) were prepared by the procedure of Davidson3.
- Publication:
-
Nature
- Pub Date:
- July 1968
- DOI:
- 10.1038/219164a0
- Bibcode:
- 1968Natur.219..164B