Uncouplers of Oxidative Phosphorylation and Teratogenic Activity of Insulin
Abstract
TREATMENT with insulin has well-established teratogenic effects in chick development. When administered during the earliest stages of incubation (first 2 days), it is responsible for the occurrence of rumplessness (chiefly absence of the tail vertebræ), whereas somewhat later (4th or 5th) day) it leads to a syndrome of micromelia and abnormalities of the beak (namely, a shortened upper beak or parrot beak). During these later stages, but not in the early ones, the teratogenic activity of insulin is strikingly exaggerated by the simultaneous administration of chlorpromazine1. The amounts of chlorpromazine which produce this effect were non-teratogenic and only moderately toxic if given alone.
- Publication:
-
Nature
- Pub Date:
- October 1964
- DOI:
- 10.1038/204285a0
- Bibcode:
- 1964Natur.204..285L