Introduction of the antibacterial drugs norfloxacin and Ciprofloxacin into a polyoxometalate structure: Synthesis, characterization, and antibacterial activity
Abstract
In this study, two new antibacterial complexes based on the quinolone antibacterial drugs Norfloxacin (NF) and Ciprofloxacin (CF) and the polyoxometalates (POMs) were synthesized, that is, [CoII(C16H18FN3O3)2]2H4[SiW12O40]·6H2O (1) and [Co II (C17H18FN3O3)2]2H4[SiW12O40]·2H2O (2). Then the complexes were comprehensively characterized by elemental analysis, infrared (IR) spectroscopy, and X-ray single-crystal diffraction. Single-crystal structural analysis revealed that complexes 1 and 2 were made up of SiW12 clusters, binuclear cobalt clusters, and water molecules. Moreover, it was observed that the SiW12 clusters in complexes 1 and 2 formed inorganic chains through covalent bonds and three-dimensional (3D) supramolecular structures through noncovalent N⋯O interactions. In this work, we also assessed the antibacterial activities of complexes 1 and 2 using Escherichia coli, Staphylococcus aureus, and Bacillus subtilis strains. In general, it was found that the antibacterial activities of complexes 1 and 2 were slightly higher than those of free NF and CF at the same mass concentrations. Furthermore, we evaluated the capacity of complexes 1 and 2 to bind to calf thymus DNA (CT-DNA) using spectroscopic titrations in the UV range. These studies showed that complexes 1 and 2 bound to CT-DNA with binding constants (Kb) of 4.1 × 104 and 1.6 × 104 M L-1, respectively, which were somewhat lower than those of pure NF and CF (8.2 × 104 and 4.9 × 104 M L-1), respectively. These results indicated that the introduction of different drug molecules into the POM system can affect their antibacterial activities.
- Publication:
-
Journal of Molecular Structure
- Pub Date:
- April 2020
- DOI:
- 10.1016/j.molstruc.2019.127584
- Bibcode:
- 2020JMoSt120527584Z
- Keywords:
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- Polyoxometalate;
- Antibacterial;
- Crystal structure;
- Norfloxacin;
- Ciprofloxacin