Porous rod-like MgO complex membrane with good anti-bacterial activity directed by conjugated linolenic acid polymer
Abstract
The problem of infection in the tissue engineering substitutes is driving us to seek new coating materials. We previously found that conjugated linolenic acid (CLnA) has well biocompatibility and excellent membrane-forming property. The objective of this study is to endow the anti-bacterial activity to CLnA membra ne by linking with MgO. The results showed that the CLnA polymer membrane can be loaded with porous rod-like MgO and such complex membrane showed anti-bacterial sensitivity against gram-positive bacteria ( Staphylococcus aureus) even at the low concentration (0.15 μg/mm2). In the present study, the best zone of inhibition got to 18.2 ± 0.8 mm when the amount of MgO reach 2.42 ± 0.58 μg/mm2. It was deduced that the porous rod-like structure of MgO was directed by CLnA in its polymerization process. Such CLnA/MgO complex membrane can be helpful in the tissue engineering, medicine, food engineering, food preservation, etc. on the basis of its good anti-bacterial activity.
- Publication:
-
Journal of Nanoparticle Research
- Pub Date:
- February 2016
- DOI:
- 10.1007/s11051-016-3338-9
- Bibcode:
- 2016JNR....18...33W
- Keywords:
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- CLnA;
- MgO;
- Anti-bacterial activity;
- Complex membrane;
- Nanostructured membrane;
- Tissue engineering applications