The SWI/SNF chromatin remodeling complex regulates germinal center formation by repressing Blimp-1 expression
Abstract
Germinal center (GC) response is central for generation of memory B cells and plasma cells that produce high-affinity antibodies, which are crucial for protective immunity against various foreign antigens. Even though key genetic factors for the GC formation are known, it is largely unknown how this process is controlled by epigenetic factors. Here we have demonstrated that the activity of SWI/SNF chromatin remodeling complex is required for the development of both GC B cells and follicular helper T cells. The SWI/SNF complex modulates Bcl-6-mediated Blimp-1 repression, and thus plays as a key mediator in the GC response. Our results provide fundamental insights into the epigenetic regulation in the GC reaction.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- February 2015
- DOI:
- 10.1073/pnas.1418592112
- Bibcode:
- 2015PNAS..112E.718C