In Situ Controlled Release of Dopamine for Treatment of Parkinson's Disease
Abstract
Parkinson's disease (PD) is a progressive, neurodegenerative disorder of the central nervous system. The primary symptoms of PD result from greatly reduced activity of dopamine-secreting cells due to cell death in the pars compacta region of the substantia nigra. The loss of dopamine as a result of death of dopamine neurons accounts for most of the movementrelated symptoms of the disease. There is no cure for Parkinson's disease, but medications can provide relief from the symptoms. Since dopamine cannot cross the hemathoencephalic barrier, the drug delivery to the brain remains a big challenge. In this chapter we will discuss a novel way of dopamine release in situ from inorganic nanostructured reservoirs that may be potentially used in PD treatment.
- Publication:
-
Nanopharmaceutics: The Potential Application of Nanomaterials. Edited by Liang Xing-Jie. Published by World Scientific Publishing Co. Pte. Ltd
- Pub Date:
- September 2013
- DOI:
- 10.1142/9789814368674_0016
- Bibcode:
- 2013npam.book..445L
- Keywords:
-
- Parkinson's disease;
- inorganic nanostructured reservoir;
- dopamine