Linewidth Narrowing for 31Phosphorus MRI of Bones
Abstract
Bone is a particularly challenging tissue to study with conventional MRI given the relatively low water density and wider linewidths of its solid components. Recent fundamental research in quantum computing gave rise to a new NMR pulse sequence that can be used to narrow the broad NMR spectrum of solids. Here we narrow the spectrum of the 31 P in natural bone mineral (by a factor of up to 1600x). This technique offers a new route to do high spatial resolution, 3D 31 P MRI of bone which complements conventional MRI and x-ray based techniques to study bone physiology and structure. Thus far we have used our pulse sequence to do high spatial resolution (sub-250 μ m)3 3 D 31 P MRI of ex vivo dry bovine cortical bones, wet procine rib bones, and wet rabbit femoral bones at 4T. We have also explored the use of compressive sampling to push imaging time down to less than two hours without distracting artifacts.
F. W. Wehrli, J. MRI 25, 390 (2007); S. Anumula et al., Bone 42, 405 (2008); D. Idiyatullin et al., J. Mag Res 193, 267 (2008); E.E. Sigmund et al., NMR Biomed 22, 436 (2009); Y. Wu et al., J. MRI 31, 954 (2010)- Publication:
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APS March Meeting Abstracts
- Pub Date:
- March 2011
- Bibcode:
- 2011APS..MARD21007F