The effects of DL-threo-β-benzyloxyaspartate (DL-TBOA) on the synaptosomal glutamate release in media low in [Na+] under artificial gravity
Abstract
L-glutamate release from cytosolic pool of brain synaptosomes after exposure of rats to artificial gravity loading was investigated using the inhibitor of glutamate transport as a tool. The nontransportable competitive inhibitor DL-threo-beta-benzyloxyaspartate (DL-TBOA) was demonstrated to become more potent in Na+ and NMDG-supplemented media under centrifuge-induced hypergravity. We showed that DL-TBOA inhibited L-[14C] glutamate release effectively in NMDG-supplemented media in comparison with Na+-supplemented one.
- Publication:
-
Kosmichna Nauka i Tekhnologiya
- Pub Date:
- 2006
- Bibcode:
- 2006KosNT..12a..90B
- Keywords:
-
- Space Technology