Structure and mechanism of interleukin-lβ converting enzyme
Abstract
Interleukin-lβ converting enzyme (ICE) processes an inactive precursor to the proinflammatory cytokine, interleukin-lβ, and may regulate programmed cell death in neuronal cells. The high-resolution structure of human ICE in complex with an inhibitor has been determined by X-ray diffraction. The structure confirms the relationship between human ICE and cell-death proteins in other organisms. The active site spans both the 10 and 20K subunits, which associate to form a tetramer, suggesting a mechanism for ICE autoactivation.
- Publication:
-
Nature
- Pub Date:
- July 1994
- DOI:
- 10.1038/370270a0
- Bibcode:
- 1994Natur.370..270W