Role of smooth muscle activation in the static and dynamic mechanical characterization of human aortas

The rupture of aortic aneurysms causes around 10,000 deaths each year in the United States. Prosthetic tubes for aortic repair present a large mismatch of mechanical properties with the natural aorta, which has negative consequences for perfusion. This motivates research into the mechanical characterization of human aortas to develop a new generation of mechanically compatible aortic grafts. Experimental data and a suitable material model for human aortas with vascular smooth muscle (VSM) activation are not available. Hence, the present study provides experimental data that are needed. These data made it possible to develop a precise structure-based model of active aortic tissue. The results show the importance of VSM activation on the static and dynamic mechanical response of human aortas.