Determinants of serum half-lives for linear and branched perfluoroalkyl substances after long-term high exposure—A study in Ronneby, Sweden

This study provides refined estimates of the half-life of eight PFAS, especially including the branched PFOS-isomers. The determinants leading to shorter half-life were young age; better kidney function; female gender in fertile age; and possibly gut inflammation and lower gut permeability. The result also suggested a time-dependent PFAS elimination process, with more rapid elimination in the first year after the end of exposure, than later.