Towards optimal thermal distribution in magnetic hyperthermia
Abstract
A linear combination of spherically symmetric heat sources is shown to provide optimal stationary thermal distribution in magnetic hyperthermia. Furthermore, such spatial location of heat sources produces suitable temperature distribution in biological medium even for assemblies of magnetic nanoparticles with a moderate value of specific absorption rate (SAR), of the order of 100  150 W/g. We also demonstrate the advantage of using assemblies of magnetic nanocapsules consisting of metallic iron nanoparticles covered with non magnetic shells of sufficient thickness in magnetic hyperthermia. Based on numerical simulation we optimize the size and geometric structure of biocompatible capsules in order to minimize the influence of strong magnetodipole interaction between closely spaced nanoparticles. It is shown that assembly of capsules can provide sufficiently high SAR values of the order of 250  400 W/g at moderate amplitudes H = 50  100 Oe and frequencies f = 100  200 kHz of alternating magnetic field, being appropriate for application in clinics
 Publication:

arXiv eprints
 Pub Date:
 October 2021
 arXiv:
 arXiv:2110.06883
 Bibcode:
 2021arXiv211006883R
 Keywords:

 Physics  Applied Physics;
 Condensed Matter  Mesoscale and Nanoscale Physics
 EPrint:
 8 pages, 4 figures