Inversion symmetry is a key symmetry in unconventional superconductors, and even its local breaking can have profound implications. For inversion-symmetric systems, there is a competition on a microscopic level between the spin-orbit coupling associated with the local lack of inversion and hybridizing terms that "restore" inversion. Investigating a layered system with alternating mirror-symmetry breaking, we study this competition considering the spin response of different superconducting order parameters for the case of strong spin-orbit coupling. We find that signatures of the local noncentrosymmetry, such as an increased spin susceptibility in spin-singlet superconductors for T →0 , persist even into the quasi-three-dimensional regime. This leads to a direction-dependent spin response that allows us to distinguish different superconducting order parameters. Furthermore, we identify several regimes with possible topological superconducting phases within a symmetry-indicator analysis. Our results may have direct relevance for the recently reported Ce-based superconductor CeRh2As2 and beyond.