Homogeneous antibody and CAR-T cells with improved effector functions targeting SSEA-4 glycan on pancreatic cancer
Abstract
Pancreatic cancer treatments remain challenging due to late diagnosis and intrinsic resistance to conventional treatments. In this study, we demonstrate the use of the homogeneous SSEA-4 antibody and CAR-T cells for effective treatment in pancreatic cancer and suggest that targeting SSEA-4 has the potential to treat pancreatic cancer.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- December 2021
- DOI:
- 10.1073/pnas.2114774118
- Bibcode:
- 2021PNAS..11814774L