AstroSat is India's first dedicated astronomical observatory in space with multi-wavelength payload on a single platform. It enables simultaneous observations in the desired wavebands. The increase in the number of payloads has also led to an increase in the complexity in space segment design, ground segment design, and mission operation management. Each payload instrument and mainframe has its own constraint for the operation, which needs to be satisfied to ensure the safety of the systems. In this paper, we explain the challenges in ground operations for mission management with various constraints. Also, we list the various constraints, both geometric and otherwise, with respect to the mainframe systems and payload instruments of AstroSat.