Waymo's safety methodologies, which draw on well established engineering processes and address new safety challenges specific to Automated Vehicle technology, provide a firm foundation for safe deployment of Waymo's Level 4 ADS, which Waymo also refers to as the Waymo Driver. Waymo's determination of its readiness to deploy its AVs safely in different settings rests on that firm foundation and on a thorough analysis of risks specific to a particular Operational Design Domain. Waymo's process for making these readiness determinations entails an ordered examination of the relevant outputs from all of its safety methodologies combined with careful safety and engineering judgment focused on the specific facts relevant for a particular determination. Waymo will approve when it determines the ADS is ready for the new conditions without creating any unreasonable risks to safety. This paper explains Waymo's methodologies as applied to the three layers of its technology: hardware, ADS behavior, and operations, and also explains Waymo's safety governance. Waymo will continue to apply and adapt those methodologies, and to learn from the important contributions of others in the AV industry, as Waymo continues to build an ever safer and more able ADS.