Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing
Abstract
Coronavirus Disease-2019 (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. Various studies exist about the molecular mechanisms of viral infection. However, such information is spread across many publications and it is very time-consuming to integrate, and exploit. We develop CoVex, an interactive online platform for SARS-CoV-2 host interactome exploration and drug (target) identification. CoVex integrates virus-human protein interactions, human protein-protein interactions, and drug-target interactions. It allows visual exploration of the virus-host interactome and implements systems medicine algorithms for network-based prediction of drug candidates. Thus, CoVex is a resource to understand molecular mechanisms of pathogenicity and to prioritize candidate therapeutics. We investigate recent hypotheses on a systems biology level to explore mechanistic virus life cycle drivers, and to extract drug repurposing candidates. CoVex renders COVID-19 drug research systems-medicine-ready by giving the scientific community direct access to network medicine algorithms. It is available at https://exbio.wzw.tum.de/covex/.
- Publication:
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Nature Communications
- Pub Date:
- July 2020
- DOI:
- 10.1038/s41467-020-17189-2
- arXiv:
- arXiv:2004.12420
- Bibcode:
- 2020NatCo..11.3518S
- Keywords:
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- Quantitative Biology - Molecular Networks
- E-Print:
- 15 pages, 4 figures