In this study we discuss the excitation of low-frequency plasma waves in the lower-middle chromosphere region of loop footpoints for the case when the plasma can be considered to be in a pre-flare state. It is shown that among the well-known semi-empirical models of the solar atmosphere, only the VAL (F) model together with a particular set of basic plasma parameters and amplitudes of the electric and magnetic fields supports generation of low-frequency wave instability. Our results show that it is possible to predict the onset of the flare process in the active region by using the interaction of kinetic Alfvén and kinetic ion-acoustic waves, which are solutions of the derived dispersion equation. The VAL (F) model allows situations when the main source of the aforementioned instability can be a sub-Dreicer electric field and drift plasma movements due to presence of spatial inhomogeneities. We also show that the generation of kinetic Alfvén and kinetic ion-acoustic waves can occur both, in plasma with a purely Coulomb conductivity and in the presence of small-scale Bernstein turbulence. The excitation of the small amplitude kinetic waves due to the development of low threshold instability in plasma with relatively low values of the magnetic field strength is also discussed.