Magnon-polarons are coherently mixed quasiparticles that originate from the strong magnetoelastic coupling of lattice vibrations and spin waves in magnetic-ordered materials. Recently, magnon-polarons have attracted a lot of attention since they provide a powerful tool to manipulate magnons, which is essential for magnon-based spintronic devices. In this work, we report the experimental observation of facet-dependent magnon-polarons in epitaxial ferrimagnetic F e3O4 thin films via spin Seebeck effect measurement. The critical magnetic fields for the magnon-polarons in the (110)- and (100)-oriented F e3O4 films are 1.5 and 1.8 T, respectively, which arises from the different phonon velocities along the  and  directions. As the temperature decreases, the magnon-polarons-enhanced spin Seebeck voltage decreases in both (110)- and (100)-oriented F e3O4 films, which could be attributed to the enhanced magnon-polarons scattering at elevated temperatures. This work demonstrates the crystal structure engineering in epitaxial magnetic films as a promising route to manipulate the magnon-polarons for future magnon spintronic applications.