β-Cyclodextrin modified Pt(II) metallacycle-based supramolecular hyperbranched polymer assemblies for DOX delivery to liver cancer cells
Abstract
The development of chemotherapeutic drugs for cancer treatment has been limited by problems such as adverse side effects and inefficient performance of the drugs. To deliver multiple anticancer drugs for accurate and synergistic liver cancer treatment, a Pt(II) metallacycle-based drug delivery system, with endogenous redox and nitric oxide stimuli responsiveness and two chemotherapeutic agents is designed via the orthogonal self-assembly strategy. In vitro studies demonstrate that this system has good ability to deliver hydrophobic anticancer drug doxorubicin to HepG2 liver cancer cells. It also efficiently inhibits tumor cell growth for enhanced liver cancer treatment. This study provides an opportunity for the further design of metallacycle-based drug delivery systems for cancer therapy.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- December 2020
- DOI:
- 10.1073/pnas.2007798117
- Bibcode:
- 2020PNAS..11730942C