Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates
Abstract
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19, a major pandemic that threatens millions of human lives and the global economy. We identified a large number of mammals that can potentially be infected by SARS-CoV-2 via their ACE2 proteins. This can assist the identification of intermediate hosts for SARS-CoV-2 and hence reduce the opportunity for a future outbreak of COVID-19. Among the species we found with the highest risk for SARS-CoV-2 infection are wildlife and endangered species. These species represent an opportunity for spillover of SARS-CoV-2 from humans to other susceptible animals. Given the limited infectivity data for the species studied, we urge caution not to overinterpret the predictions of the present study.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- September 2020
- DOI:
- 10.1073/pnas.2010146117
- Bibcode:
- 2020PNAS..11722311D