Multiplicative Effect Modeling: The General Case
Abstract
Generalized linear models, such as logistic regression, are widely used to model the association between a treatment and a binary outcome as a function of baseline covariates. However, the coefficients of a logistic regression model correspond to log odds ratios, while subjectmatter scientists are often interested in relative risks. Although odds ratios are sometimes used to approximate relative risks, this approximation is appropriate only when the outcome of interest is rare for all levels of the covariates. Poisson regressions do measure multiplicative treatment effects including relative risks, but with a binary outcome not all combinations of parameters lead to fitted means that are between zero and one. Enforcing this constraint makes the parameters variation dependent, which is undesirable for modeling, estimation and computation. Focusing on the special case where the treatment is also binary, Richardson et al. (2017) propose a novel binomial regression model, that allows direct modeling of the relative risk. The model uses a log oddsproduct nuisance model leading to variation independent parameter spaces. Building on this we present general approaches to modeling the multiplicative effect of a continuous or categorical treatment on a binary outcome. Monte Carlo simulations demonstrate the superior performance of our proposed methods. A data analysis further exemplifies our methods.
 Publication:

arXiv eprints
 Pub Date:
 June 2019
 arXiv:
 arXiv:1906.00558
 Bibcode:
 2019arXiv190600558Y
 Keywords:

 Statistics  Methodology