Motivated by the recent interest in nonequilibrium phenomena in quantum many-body systems, we study strongly interacting fermions on a lattice by deriving and numerically solving quantum Boltzmann equations that describe their relaxation to thermodynamic equilibrium. The derivation is carried out by inspecting the hierarchy of correlations within the framework of the 1 /Z expansion. Applying the Markov approximation, we obtain the dynamic equations for the distribution functions. Interestingly, we find that in the strong-coupling limit, collisions between particles and holes dominate over particle-particle and hole-hole collisions—in stark contrast to weakly interacting systems. As a consequence, our numerical simulations show that the relaxation timescales strongly depend on the type of excitations (particles or holes or both) that are initially present.