An ensemble of flexible conformations underlies mechanotransduction by the cadherin-catenin adhesion complex
Abstract
Adherens junctions are specialized cell-cell adhesion complexes found in epithelial, endothelial, and neuronal tissues of multicellular organism. The cadherin-catenin complex is the core component of the adherens junction and transmits mechanical stress from cell to cell. This study reveals that the cadherin-catenin complex displays a wide spectrum of flexible structures, which suggests a dynamic mechanism for this complex in mechanotransduction for cell-cell adhesion.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- October 2019
- DOI:
- 10.1073/pnas.1911489116
- Bibcode:
- 2019PNAS..11621545B