Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling
Abstract
The function of α-synuclein (α-syn) has been long debated, and two seemingly divergent views have emerged. In one, α-syn binds to VAMP2, acting as a SNARE chaperone—but with no effect on neurotransmission—while another posits that α-syn attenuates neurotransmitter release by restricting synaptic vesicle mobilization and recycling. Here, we show that α-syn-VAMP2 interactions are necessary for α-syn-induced synaptic attenuation. Our data connect divergent views and suggest a unified model of α-syn function.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- June 2019
- DOI:
- 10.1073/pnas.1903049116
- Bibcode:
- 2019PNAS..11611113S