TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival
Abstract
Zn2+, Mg2+, and Ca2+ are the most abundant divalent metals in mammals. Different categories of cation-selective channels and transporters are thought to control the levels of individual metals in a cell-specific manner. However, the mechanisms responsible for the organismal balance of these minerals are poorly understood. Using genetic mouse models together with biophysical and biochemical analysis, we show that the channel-kinase TRPM7 is a master regulator of the organismal balance of divalent cations. TRPM7 activity is primarily required in the intestine, while TRPM7 function in the kidney—commonly thought to be essential—is expendable. Hence, against current thinking, organismal balance of multiple divalent cations predominantly relies on a common gatekeeper, TRPM7, rather than on individual specialized channels/transporters.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- March 2019
- DOI:
- 10.1073/pnas.1810633116
- Bibcode:
- 2019PNAS..116.4706M