Pharmacological characterization of the aminorex analogs 4-MAR, 4,4‧-DMAR, and 3,4-DMAR
Abstract
Aminorex derivatives were characterized in vitro. 4,4‧-DMAR inhibited monoamine transport with a preference for the SERT and weakly interacted with the 5-HT2A receptor. 4-MAR mainly inhibited the DAT and NET. 3,4-DMAR was only a weak NET inhibitor. The findings suggest that 4,4‧-DMAR and 4-MAR exert psychoactive and toxic effects similar to MDMA and amphetamine, respectively.
- Publication:
-
NeuroToxicology
- Pub Date:
- May 2019
- DOI:
- Bibcode:
- 2019NeuTx..72...95R
- Keywords:
-
- Aminorex;
- 4-methylaminorex;
- 4;
- 4‧-dimethylaminorex;
- 3;
- 4-dimethylaminorex;
- Novel psychoactive substance;
- Monoamine