Chemosensing, molecular docking and antioxidant studies of 8-aminoquinoline appended acylthiourea derivatives
Abstract
Acylthiourea derivatives, 1-benzoyl-3-(quinolin-8-yl)thiourea (1), 1-(furan-2-carbonyl)-3-(quinolin-8-yl)thiourea (2) and 1-(thiophene-2-carbonyl)-3-(quinolin-8-yl)thiourea (3) were synthesized and well characterized by using NMR (1H and 13C), FT-IR, UV-visible and mass spectroscopy tools. The molecular structures of compounds 1 and 3 were confirmed by single crystal X-ray crystallography. The fluorescence emission of the compounds (1-3) was studied using fluorescence spectrophotometer. The sensing ability of the acylthiourea derivatives was analyzed by colorimetric, UV-visible and fluorescence titrations. In silico anti-inflammatory, antimalarial and anti-tuberculosis activities were investigated using molecular docking studies. Acylthiourea derivatives also possessed good antioxidant activity.
- Publication:
-
Journal of Molecular Structure
- Pub Date:
- June 2019
- DOI:
- 10.1016/j.molstruc.2019.02.098
- Bibcode:
- 2019JMoSt1185..450K
- Keywords:
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- 8-aminoquinoline;
- Acylthiourea;
- Chemosensor;
- Molecular docking;
- Antioxidant