The application of design-point-based reliability-based design optimization (RBDO) methods is hindered by the challenge of multiple-design-point problems. In this article, to improve the commonality of design-point-based RBDO methods, a novel multiple-design-point (MDP) approach is developed. The MDP approach uses the trace of the design points from consequent reliability analysis iterations to identify whether there are multiple design points, then all of the design points are used to calculate shifting vectors for the sequential optimization and reliability assessment method, and the corresponding probabilistic constraints are moved to the feasible region along these multiple shifting vectors at the same time. With multiple shifted probabilistic constraints, the design feasibility associated with this probabilistic constraint will be satisfied. Two mathematical examples, a speed reducer design and a honeycomb crashworthiness design, are presented to validate the effectiveness of the MDP method. The results show that the MDP approach is effective for handling multiple-design-point problems.