Differentiated T-Cells Ratio in the Immune Response in Residents of Arctic and Middle Zone of the Russian Federation
Abstract
The climate and environment of the northern and central regions of Russia have a significant impact on human health and, particularly, immune system, especially in women. Exposed to adverse conditions, the immune status is characterized by a short period of resistance, deficiency of T-cell population, weakened reserve capacity of immune homeostasis, and increased incidence of immune disorders. A study has been conducted to identify the ratio of differentiated T-cells in the immune response in healthy, working women aged 40-60, residing in the settlement of Pinega (Arkhangelsk Region) and the city of Vologda. The study has revealed leukopenia in 35.5% of Pinega women and lymphopenia in 31.8% of Vologda women. Regardless of the area of residence, 94.0% of the surveyed have deficit of mature T-lymphocytes (CD3+). The deficit of T-helper cells (CD4+) is suffered by 34.1% of Vologda women and 22.2% of Pinega ones. Furthermore, an increased content of cytotoxic T-lymphocytes and natural killer cells was detected in approximately 66% of Vologda and Pinega women.
- Publication:
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IOP Conference Series: Earth and Environmental Science
- Pub Date:
- April 2019
- DOI:
- 10.1088/1755-1315/263/1/012031
- Bibcode:
- 2019E&ES..263a2031K