3D printing of a wearable personalized oral delivery device: A first-in-human study
Abstract
The performance of a 3D-printed personalized sustained delivery device is demonstrated for the first time in humans.Despite the burgeoning interest in three-dimensional (3D) printing for the manufacture of customizable oral dosage formulations, a U.S. Food and Drug Administration-approved tablet notwithstanding, the full potential of 3D printing in pharmaceutical sciences has not been realized. In particular, 3D-printed drug-eluting devices offer the possibility for personalization in terms of shape, size, and architecture, but their clinical applications have remained relatively unexplored. We used 3D printing to manufacture a tailored oral drug delivery device with customizable design and tunable release rates in the form of a mouthguard and, subsequently, evaluated the performance of this system in the native setting in a first-in-human study. Our proof-of-concept work demonstrates the immense potential of 3D printing as a platform for the development and translation of next-generation drug delivery devices for personalized therapy.
- Publication:
-
Science Advances
- Pub Date:
- May 2018
- DOI:
- 10.1126/sciadv.aat2544
- Bibcode:
- 2018SciA....4.2544L