We study two cases of interrelations between the enhancement of symmetries in the infrared (IR) and duality properties of supersymmetric quantum field theories in four dimensions. First, we discuss an S U (2 ) N =1 model with four flavors, singlet fields, and a superpotential. We show that this model flows to a conformal field theory with E6×U (1 ) global symmetry. The enhancement of the flavor symmetry follows from Seiberg duality. The second example is concerned with an S U (4 ) gauge theory with matter in the fundamental and antisymmetric representations. We argue that this model has enhanced S O (12 ) symmetry in the IR, and, guided by this enhancement, we deduce a new IR duality.