Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociception
Abstract
Bioactive lipids control a wide variety of physiologic processes. We have recently identified a branch of bioactive lipid signaling mediated by N-acyl amino acids (NAAs) and the circulating enzyme peptidase M20 domain-containing 1 (PM20D1). Here we generate and characterize mice globally deficient in PM20D1. These PM20D1-KO mice have bidirectional changes in NAA levels in blood and tissues and exhibit a variety of metabolic and nociceptive phenotypes. Our findings elucidate the endogenous physiologic functions for NAA signaling in vivo and suggest PM20D1 inhibitors might be useful for the treatment of pain.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- July 2018
- DOI:
- 10.1073/pnas.1803389115
- Bibcode:
- 2018PNAS..115E6937L