Distinct human circulating NKp30+FcεRIγ+CD8+ T cell population exhibiting high natural killer-like antitumor potential
Abstract
CD8+ T cell recognition of tumor cells is typically based on the detection of specific MHC-peptide complexes, while natural killer (NK) cell recognition relies on the detection of NK ligands by an array of NK receptors. In this study we uncovered a distinct small population of CD8+ T cells expressing NKp30, a potent activating NK receptor, on peripheral blood from healthy donors. Those innate-like CD8+ T cells, coexpressing FcεRIγ and PZLF, could be generated and differentiated from a population of peripheral blood CD8+ T cells as result of IL-15-driven acquisition of broad innate features. This unique effector population could potently control the growth of tumors in an NK-like manner, making it promising for cancer immunotherapy by its dual target-recognition potential.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- June 2018
- DOI:
- 10.1073/pnas.1720564115
- Bibcode:
- 2018PNAS..115E5980C