Transcriptional factor ICER promotes glutaminolysis and the generation of Th17 cells
Abstract
Th17 cells unlike other CD4+ T helper subsets use glutaminolysis as a source of energy and upregulate Gls1. Inhibition of Gls1 ameliorates Th17 differentiation in vitro and experimental autoimmune encephalomyelitis in mice. Mechanistically this is accomplished through the upregulation of Gls1 by the Th17-promoting transcription factor, inducible cAMP early repressor (ICER). These findings claim an essential role of glutaminolysis in the generation of Th17 cells and offer an approach to control diseases linked to their generation.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- March 2018
- DOI:
- 10.1073/pnas.1714717115
- Bibcode:
- 2018PNAS..115.2478K