As the performance of smart cellphone improves constantly, the design of website interface of cellphone becomes more and more diversified and is constantly optimized and updated. The construction of cellphone website is the currently most popular website construction way in market and the design of website design of smart cellphone can embody the advanced technology of cellphone terminal. The research has analyzed the perceived quality and degree of satisfaction of users according to the current situation of design of website interface of smart cellphone in the current period. And it also has analyzed and studied the tone, layout and interactive mode of website interface of cellphone. Other than prospective design thought, the paper aims to propose convenient, humanized and highly efficient methods regarding design of website interface of cellphone and improvement and optimization methods through human engineering theories to enable users to finish the operation of cellphone website through the simplest way. The paper adopts examples and data analysis method to analyze and solve problems. The sense of convenience and fastness and operation habits while using cellphone website will become the mainstream demands. And the design of website interface of cellphone also should conform to the aesthetics of people. The reasonable and scientific layout of website interface and information structure will raise the perception and experience of cellphone website by users to a higher level.