The preparation and the sustained release of titanium dioxide hollow particles encapsulating L-ascorbic acid
Abstract
The preparation of the titanium dioxide hollow particles encapsulating L-ascorbic acid via sol-gel process using inkjet nozzle has been performed, and the sustained release and the effect protecting against degradation of L-ascorbic acid in the particles were investigated. The morphology of titanium dioxide particles was evaluated by scanning electron microscopy (SEM) and energy dispersive X-ray spectrometry (EDS). The sustained release and the effect protecting against degradation of L-ascorbic acid were estimated by dialysis bag method in phosphate buffer saline (PBS) (pH = 7.4) as release media.
The prepared titanium dioxide particles exhibited spherical porous structures. The particle size distribution of the titanium dioxide particles was uniform. The hollow titanium dioxide particles encapsulating L-ascorbic acid showed the sustained release. It was also found that the degradation of L-ascorbic acid could be inhibited by encapsulating L-ascorbic acid in the titanium dioxide hollow particles.- Publication:
-
Journal of Crystal Growth
- Pub Date:
- May 2018
- DOI:
- 10.1016/j.jcrysgro.2018.03.008
- Bibcode:
- 2018JCrGr.490...11T
- Keywords:
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- A1. Biomaterials;
- A1. Crystal morphology;
- A1. Interfaces;
- B1. Titanium compounds