Sydney is Australia’s largest city and is growing rapidly. Although Sydney’s air quality is relatively good compared to the major cities in many industrialised countries, particulate matter (PM) and ozone (O3) occasionally exceed the national health standards and are the cause of premature mortalities and hospital admissions. Numerous studies from overseas (e.g. North America and continental Europe) suggest that climate change may impact air quality to the detriment of human health. There is limited knowledge about how climate change may impact air quality in Sydney. This study reviews the available literature on the impacts of climate change on air quality related health impacts in Sydney to identify knowledge and research gaps. Where no studies are available for Sydney, it draws on relevant studies from other Australian cities and overseas. Our findings summarise what is known about how climate change may impact air quality in Sydney and where research gaps exist. This approach can facilitate research agendas, policies and planning strategies that mitigate public health impacts and tackle climate change and air pollution in a coordinated way.