Stability studies of oxytetracycline in methanol solution
Abstract
As one kind of typical tetracycline antibiotics, antibiotic residues of oxytetracycline have been frequently detected in many environmental media. In this study, the stability of oxytetracycline in methanol solution was investigated by high-performance liquid chromatography combined with UV-vis (HPLC-UV). The results show that the stability of oxytetracycline in methanol solution is highly related to its initial concentration and the preserved temperature. Under low temperature condition, the solution was more stable than under room temperature preservation. Under the same temperature preservation condition, high concentrations of stock solutions are more stable than low concentrations. The study provides a foundation for preserving the oxytetracycline-methanol solution.
- Publication:
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IOP Conference Series: Earth and Environmental Science
- Pub Date:
- February 2018
- DOI:
- 10.1088/1755-1315/113/1/012110
- Bibcode:
- 2018E&ES..113a2110W