Fabrication and characterization of magnetic-vortex microdiscs for applying force in mechanobiological systems
Applying controlled, localized force in 3D mechano-biological systems has been a technical hurdle for probing cell mechanics. Bio-functionalized magnetic microdiscs have been used to apply force to cancer cells triggering apoptosis because of the advantage of a near zero stray field magnetic vortex configuration that prevents agglomeration when in solution. In this work, we have fabricated discs with diameters ranging from 0.5 - 10 μm through lithography and sputtering. To guide the design of the microdiscs for biological applications, micromagnetic simulations, formulated with the Landau-Lifshitz equation, were performed using MUMAX3. Atomic force microscopy, small angle x-ray reflectivity, and scanning electron microscopy results confirm the desired characteristics of the discs.This research was supported by the Center for Engineering MechanoBiology through a Grant from the National Science Foundation's STC program (CCMI): 15-48571.
APS March Meeting Abstracts
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