Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis
Abstract
β-Arrestins (βarrs) interact with G protein-coupled receptors (GPCRs) to desensitize G protein signaling, initiate signaling on their own, and mediate receptor endocytosis. Using a panel of GPCRs believed to couple differently to βarrs, we demonstrate how distinct conformations of GPCR-βarr complexes are specialized to perform different subsets of these cellular functions. Our results thus provide a new signaling paradigm for the understanding of GPCRs, whereby a specific GPCR-βarr conformation mediates receptor desensitization, and another drives internalization and some forms of signaling.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- March 2017
- DOI:
- 10.1073/pnas.1701529114
- Bibcode:
- 2017PNAS..114.2562C